Mitomycin C
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Replied by admin on topic Mitomycin C
Posted 18 May 2019 15:17
A little bit of science for the weekend 
Those of you who, like me, without being fully informed, had Mitomycin C applied before surface ablation treatment (lasek/PRK) will no doubt find this 2012 paper as scary as I do!
'What We Don’t Know
“We’re doing surface ablations in patients who are 21 years old. We really don’t know what effect this will have when they’re 70,” Dr. Wilson said. Forty years from now, will ophthalmologists be seeing stromal melting or unhealthy epithelium in these eyes? “I’ve never seen anything to suggest that it’s going to be a problem, but my understanding of corneal biology makes me continue to worry about it.”*
Dr. Majmudar agreed that long-term safety remains a concern. Nonetheless, he noted, “We’ve seen enough patients treated over the past 15 years that if problems were going to occur, we would likely have seen some hint of them by now.”**
While it’s reassuring to see patients who are doing well many years later, Dr. Hofmeister stressed that MMC is used off label. “It’s an area of extreme controversy,” she said. “We’re taking healthy eyes that see well [and treating them]. Above all, we don’t want to harm people.”'***
www.aao.org/eyenet/article/15-years-of-m...tion-tips-techniques
* (i) I was 57 when I had laser eye surgery!
(ii) If Dr Wilson is worried, then those of us who've had MMC sure as hell should be!
**Liar - they've seen more than 'some hint' of problems!
***I repeat, liar! They harm people as a matter of course, then treat us like lab rats, to be discussed, dissected, 'let's test this on the next one...'
And of course laughed at by sickos like Parag Majmudar and his colleagues - the surgeon who 'entertained' colleagues by mocking suicidal patients in his disgusting performance at an ASCRS convention in 2009, YouTube video posted here 15 March.
As for laser or lens replacement surgery age suitability, this should be of interest if you haven't previously seen it!
PS: Like so many ex-Optical Express surgeons, no mention of his previous employer here... www.communityhealthservices.co.uk/ourcli...tonio-uceda-montanes
Or here... optilase.com/our-surgeons/
Wayne Crewe-Brown coincidentally OE's choice of medicolegal defence expert!
Those of you who, like me, without being fully informed, had Mitomycin C applied before surface ablation treatment (lasek/PRK) will no doubt find this 2012 paper as scary as I do!
'What We Don’t Know
“We’re doing surface ablations in patients who are 21 years old. We really don’t know what effect this will have when they’re 70,” Dr. Wilson said. Forty years from now, will ophthalmologists be seeing stromal melting or unhealthy epithelium in these eyes? “I’ve never seen anything to suggest that it’s going to be a problem, but my understanding of corneal biology makes me continue to worry about it.”*
Dr. Majmudar agreed that long-term safety remains a concern. Nonetheless, he noted, “We’ve seen enough patients treated over the past 15 years that if problems were going to occur, we would likely have seen some hint of them by now.”**
While it’s reassuring to see patients who are doing well many years later, Dr. Hofmeister stressed that MMC is used off label. “It’s an area of extreme controversy,” she said. “We’re taking healthy eyes that see well [and treating them]. Above all, we don’t want to harm people.”'***
www.aao.org/eyenet/article/15-years-of-m...tion-tips-techniques
* (i) I was 57 when I had laser eye surgery!
(ii) If Dr Wilson is worried, then those of us who've had MMC sure as hell should be!
**Liar - they've seen more than 'some hint' of problems!
***I repeat, liar! They harm people as a matter of course, then treat us like lab rats, to be discussed, dissected, 'let's test this on the next one...'
And of course laughed at by sickos like Parag Majmudar and his colleagues - the surgeon who 'entertained' colleagues by mocking suicidal patients in his disgusting performance at an ASCRS convention in 2009, YouTube video posted here 15 March.
As for laser or lens replacement surgery age suitability, this should be of interest if you haven't previously seen it!
PS: Like so many ex-Optical Express surgeons, no mention of his previous employer here... www.communityhealthservices.co.uk/ourcli...tonio-uceda-montanes
Or here... optilase.com/our-surgeons/
Wayne Crewe-Brown coincidentally OE's choice of medicolegal defence expert!
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Replied by admin on topic Mitomycin C
Posted 22 Sep 2018 14:10
Most of you won't have heard of Mitomycin C (MMC), a drug generally used in cancer treatment
en.wikipedia.org/wiki/Mitomycin_C
www.cochrane.org/CD002897/EYES_mitomycin-c-for-glaucoma-surgery
Although unlicensed for use in laser eye surgery, there are few clinics/surgeons that do not use MMC for lasek/PRK. But unfortunately, we guinea pigs are not always advised of the facts, and even when we are they're presented in such a casual way that we don’t worry because the doctor knows best - or so we all believed once upon a time!
MMC was not mentioned or discussed with me at any point prior to the moment when Optimax surgeon Wilbert Hoe thrust the four page MMC consent form in front of me minutes before surgery - allowing me no time to research it - telling me nothing more than it was to stop post op haze, and to sign it.
Given the way it was presented to me I accepted that it was no big deal, so I signed the MMC Consent form without time to read.
In fact, it was a massive big deal!
And had I been fully informed pre surgery, and given an opportunity to research the drug, then I wouldn’t be talking to you now, because there is no way I would have agreed to having MMC administered to my eyes.
It was only post surgery, realising that I had serious problems, that I read the MMC Consent, which states that, ‘Optimax does not endorse the use of Mitomycin-C in it’s [sic] clinics and recommends the non-use of Mitomycin-C in all cases where there is an alternative option (e.g. waiting). Most haze will clear with time. Medical practitioners treating with this drug do so determined by their own clinical judgement and take responsibility for any after effects due to its use experienced by individual and properly informed patients.’
If 'most haze will clear with time', then I should have been given the option to refuse. And I challenge anyone in the industry who dares argue that I was given a choice to contact me, and I'll be happy to debate this publicly!
And if Optimax don't endorse its use, then who provides the MMC? Does the doctor walk around with it in his bag, or is it ordered from Optimax’ pharma supplier? In which case this surely negates their claim that they do ‘not endorse the use of Mitomycin-C'!
'If ethanol [alcohol] use during LASEK produces similar effects as MMC, MMC will not be as necessary as in conventional PRK’
pdfs.semanticscholar.org/a986/7a865ce98c...35f5e6e93c610445.pdf
Alcohol was also used on my eyes during lasek...
'Even though ophthalmologists have 15 years of experience with Mitomycin C (MMC) to treat and prevent corneal haze following surface ablation, questions still abound regarding its optimal use and long-term safety.’
www.aao.org/eyenet/article/15-years-of-m...tion-tips-techniques
Reading through my Optimax MMC consent form earlier,I was horrified to read a paragraph that included this from US ophthalmologist Dr Randy Epstein, suggesting that, ‘the appropriateness of using Mitomycin-C prophylactically is likely to be more controversial when performing myopic PRK or LASEK in eye which are poor LASIK candidates because of thin corneas or large pupils.’
I had thin corneas and large pupils, though the latter was never addressed pre surgery.
I asked a number of surgeons for copies of their MMC consent forms, one of which included the following info, 'MMC is very potent and potentially toxic under certain circumstances. Complications are very rare and some eye-related complications that have been reported following the use of MMC (for other conditions – NOT Laser eye surgery) include: conjunctival injection (redness of the eye), permanent stem cell deficiency, corneal or scleral thinning or perforation, corneal de-compensation requiring corneal transplantation, cataract, and retinal vascular occlusion. The complications listed above were seen following various types of eye surgeries and possibly with incorrect dosage and concentration of MMC.’
Regular readers will know that I suffered two retinal vein occlusions last year, which caused a macular oedema. This was treated with monthly injections until the swelling reduced, and just as I was optimistically expecting to be told no more injections, another oedema occurred!
Whilst no retinal surgeon could tell me whether the occlusions have anything to do with my laser surgery, other than being stress related, I will always argue that any problems I suffer with my eyes, without a definitive known cause, are a result of laser. And I was therefore not too surprised to read that MMC has been linked to occlusions after eye surgery. The caveat ‘NOT laser’ is as convincing to me as the industry’s claim that laser eye surgery does not cause dry eyes ar MGD.
Only retinal surgeons at Moorfields have details of my branch retinal vein occlusions (BRVO). In my opinion therefore, the possibility of a connection to laser surgery cannot be so easily dismissed by refractive surgeons, and until data is collected detailing the numbers who’ve similarly suffered occlusions after laser, their argument is as valid as mine, possibly less so.
I have read many research papers written by (refractive) surgeons comparing studies of lasik v lasek etc, but little time is spent researching the post op problems we all suffer! Because if this were honestly investigated, without skewed data to suit their own agenda (£$) and the truth told, the numbers of people undergoing laser/RLE would plummet, and thousands of surgeons worldwide would be scrabbling for new jobs!
And when I read research papers referring to the effect of laser eye surgery/MMC on countless rabbits’ eyes I want to cry, because the pain these animals must suffer is inconceivable. At least I knew the cause of the intense and relentless pain I suffered for three days post op, and understand why I still suffer pain and can’t see very well, and that no amount of carrots will ever help me see in the dark again, but what those poor animals must suffer horrifies me.
NB: I do not intend to enter debate concerning animal research.
While this unregulated corrupt and incestuous industry experiment on our eyes, boast about successes at their conferences and discuss more ways to f*ck up our eyes, it is entirely at the expense of our healthy eyes and quality of life.
And I am unimpressed by the industry’s reliance on meta-analytics, not least because without true statistics they’re flawed and unreliable. I deal with the end results, very real people left irreparably damaged, all for the profit of surgeons (and businessmen) who manage to sleep at night, no matter how many people they’ve hurt.
Doctors are expected to heal people, not harm them!
en.wikipedia.org/wiki/Mitomycin_C
www.cochrane.org/CD002897/EYES_mitomycin-c-for-glaucoma-surgery
Although unlicensed for use in laser eye surgery, there are few clinics/surgeons that do not use MMC for lasek/PRK. But unfortunately, we guinea pigs are not always advised of the facts, and even when we are they're presented in such a casual way that we don’t worry because the doctor knows best - or so we all believed once upon a time!
MMC was not mentioned or discussed with me at any point prior to the moment when Optimax surgeon Wilbert Hoe thrust the four page MMC consent form in front of me minutes before surgery - allowing me no time to research it - telling me nothing more than it was to stop post op haze, and to sign it.
Given the way it was presented to me I accepted that it was no big deal, so I signed the MMC Consent form without time to read.
In fact, it was a massive big deal!
And had I been fully informed pre surgery, and given an opportunity to research the drug, then I wouldn’t be talking to you now, because there is no way I would have agreed to having MMC administered to my eyes.
It was only post surgery, realising that I had serious problems, that I read the MMC Consent, which states that, ‘Optimax does not endorse the use of Mitomycin-C in it’s [sic] clinics and recommends the non-use of Mitomycin-C in all cases where there is an alternative option (e.g. waiting). Most haze will clear with time. Medical practitioners treating with this drug do so determined by their own clinical judgement and take responsibility for any after effects due to its use experienced by individual and properly informed patients.’
If 'most haze will clear with time', then I should have been given the option to refuse. And I challenge anyone in the industry who dares argue that I was given a choice to contact me, and I'll be happy to debate this publicly!
And if Optimax don't endorse its use, then who provides the MMC? Does the doctor walk around with it in his bag, or is it ordered from Optimax’ pharma supplier? In which case this surely negates their claim that they do ‘not endorse the use of Mitomycin-C'!
'If ethanol [alcohol] use during LASEK produces similar effects as MMC, MMC will not be as necessary as in conventional PRK’
pdfs.semanticscholar.org/a986/7a865ce98c...35f5e6e93c610445.pdf
Alcohol was also used on my eyes during lasek...
'Even though ophthalmologists have 15 years of experience with Mitomycin C (MMC) to treat and prevent corneal haze following surface ablation, questions still abound regarding its optimal use and long-term safety.’
www.aao.org/eyenet/article/15-years-of-m...tion-tips-techniques
Reading through my Optimax MMC consent form earlier,I was horrified to read a paragraph that included this from US ophthalmologist Dr Randy Epstein, suggesting that, ‘the appropriateness of using Mitomycin-C prophylactically is likely to be more controversial when performing myopic PRK or LASEK in eye which are poor LASIK candidates because of thin corneas or large pupils.’
I had thin corneas and large pupils, though the latter was never addressed pre surgery.
I asked a number of surgeons for copies of their MMC consent forms, one of which included the following info, 'MMC is very potent and potentially toxic under certain circumstances. Complications are very rare and some eye-related complications that have been reported following the use of MMC (for other conditions – NOT Laser eye surgery) include: conjunctival injection (redness of the eye), permanent stem cell deficiency, corneal or scleral thinning or perforation, corneal de-compensation requiring corneal transplantation, cataract, and retinal vascular occlusion. The complications listed above were seen following various types of eye surgeries and possibly with incorrect dosage and concentration of MMC.’
Regular readers will know that I suffered two retinal vein occlusions last year, which caused a macular oedema. This was treated with monthly injections until the swelling reduced, and just as I was optimistically expecting to be told no more injections, another oedema occurred!
Whilst no retinal surgeon could tell me whether the occlusions have anything to do with my laser surgery, other than being stress related, I will always argue that any problems I suffer with my eyes, without a definitive known cause, are a result of laser. And I was therefore not too surprised to read that MMC has been linked to occlusions after eye surgery. The caveat ‘NOT laser’ is as convincing to me as the industry’s claim that laser eye surgery does not cause dry eyes ar MGD.
Only retinal surgeons at Moorfields have details of my branch retinal vein occlusions (BRVO). In my opinion therefore, the possibility of a connection to laser surgery cannot be so easily dismissed by refractive surgeons, and until data is collected detailing the numbers who’ve similarly suffered occlusions after laser, their argument is as valid as mine, possibly less so.
I have read many research papers written by (refractive) surgeons comparing studies of lasik v lasek etc, but little time is spent researching the post op problems we all suffer! Because if this were honestly investigated, without skewed data to suit their own agenda (£$) and the truth told, the numbers of people undergoing laser/RLE would plummet, and thousands of surgeons worldwide would be scrabbling for new jobs!
And when I read research papers referring to the effect of laser eye surgery/MMC on countless rabbits’ eyes I want to cry, because the pain these animals must suffer is inconceivable. At least I knew the cause of the intense and relentless pain I suffered for three days post op, and understand why I still suffer pain and can’t see very well, and that no amount of carrots will ever help me see in the dark again, but what those poor animals must suffer horrifies me.
NB: I do not intend to enter debate concerning animal research.
While this unregulated corrupt and incestuous industry experiment on our eyes, boast about successes at their conferences and discuss more ways to f*ck up our eyes, it is entirely at the expense of our healthy eyes and quality of life.
And I am unimpressed by the industry’s reliance on meta-analytics, not least because without true statistics they’re flawed and unreliable. I deal with the end results, very real people left irreparably damaged, all for the profit of surgeons (and businessmen) who manage to sleep at night, no matter how many people they’ve hurt.
Doctors are expected to heal people, not harm them!
- Animal Lover
Replied by Animal Lover on topic Cruelty to rabbits as well as people!
Posted 25 Oct 2014 16:20
Can someone tell me how the f*ck a rabbit read a Snellen chart??
www.pubfacts.com/author/Kazakos+Dimitris+C
"Similarly, eyes in groups 3 and 4 underwent PRK to correct -10 D in a 6-mm optical zone, while sponges soaked with 0.02% MMC were applied on the exposed corneal stroma for 60 and 120 seconds, respectively."
Kazakos Dimitris C
I had Lasek (same pain as PRK) and MMC and it was the worst pain I could imagine for more than 3 days!!
Poor rabbits
www.pubfacts.com/author/Kazakos+Dimitris+C
"Similarly, eyes in groups 3 and 4 underwent PRK to correct -10 D in a 6-mm optical zone, while sponges soaked with 0.02% MMC were applied on the exposed corneal stroma for 60 and 120 seconds, respectively."
Kazakos Dimitris C
I had Lasek (same pain as PRK) and MMC and it was the worst pain I could imagine for more than 3 days!!
Poor rabbits
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Replied by admin on topic Mitomycin C (MMC)
Posted 17 Aug 2014 13:44
As I sit here suffering with painful and itchy dry eyes, I thought I'd refresh this topic - not so easily done to my eyes!
"Photorefractive keratectomy with mitomycin C treatment could induce or exacerbate dry eye."
This is true for Lasek, the (mis)treatment I had.
www.ncbi.nlm.nih.gov/pubmed/16722493
"Photorefractive keratectomy with mitomycin C treatment could induce or exacerbate dry eye."
This is true for Lasek, the (mis)treatment I had.
www.ncbi.nlm.nih.gov/pubmed/16722493
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